Tramadol/Acetaminophen
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Tramadol/Acetaminophen:
Seek medical attention right away if any of these SEVERE side effects occur when using Tramadol/Acetaminophen:Constipation; diarrhea; dizziness; drowsiness; increased sweating; loss of appetite; nausea.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); chest pain; confusion; difficult or painful urination; disorientation; excessive sweating; fainting; fast or irregular heartbeat; fever; hallucinations; loss of coordination; mental or mood changes (eg, agitation, depression); red, swollen, blistered, or peeling skin; seizures (convulsions); severe nausea, vomiting, or diarrhea; severe or persistent headache or dizziness; slow or shallow breathing; suicidal thoughts or behaviors; tremor; unusual tiredness or weakness; vision changes.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency
Side Effects by Body System - for Healthcare Professionals
Gastrointestinal
Gastrointestinal side effects are common. Nausea and constipation occur within the first 90 days of therapy in 40% and 46% of treated patients, respectively. Vomiting, diarrhea, dyspepsia, anorexia, flatulence, abdominal pain, and dry mouth have also been reported.
Nervous system
Seizures have been reported in patients receiving the normal recommended dose. The risk for seizures is increased with doses above the recommended range.
Nervous system side effects occur frequently. Dizziness, headache, and somnolence have been reported in more than 25% of treated patients during the first three months of therapy. CNS stimulation, including nervousness, anxiety, tremor, agitation, euphoria, emotional lability and hallucinations, has also been reported. Confusion, sleep disorders, and coordination disturbances have been reported in less than 5% of patients. Seizures have been reported in over 200 cases. Cases of long-lasting delirium have been reported in two elderly patients. A case of serotonin syndrome triggered by tramadol has also been reported.
Dermatologic
Dermatologic side effects including pruritus (11%) have been reported. Rash and urticaria have occurred rarely.
Genitourinary
Genitourinary side effects including urinary retention and urinary frequency have been reported in less than 5% of treated patients.
Cardiovascular
Cardiovascular side effects including tachycardia and orthostatic hypotension have been reported rarely.
Hypersensitivity
The use of tramadol is contraindicated for patients with a history of allergy to any opioid.
Hypersensitivity side effects including anaphylactoid reactions have been reported after first doses of tramadol as well as in patients with a documented history of codeine allergy. Angioedema has been reported rarely.
Other
Other side effects including withdrawal symptoms and, rarely, auditory hallucinations have been reported. A case of vocal cord closure has also been reported.
Metabolic
Metabolic side effects including hyponatremia have been reported
